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Vanderbilt

Posted: 7/20/2010 9:21 PM

Vanderbilt 


You are a dedicated individual and post often on the Vanderbilt forum.  Please comment on Vanderbilt current therapy , resources, class 2 and 3 research studies especially with Small cell therapy.  Please comment on your studies.
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Posted: 7/21/2010 8:13 PM

Re: Vanderbilt 


Got a link?
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Posted: 7/27/2010 8:58 PM

Re: Vanderbilt 


MY inbox
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Posted: 8/2/2010 12:18 PM

Re: Researchers Find Safer Way to Produce Stem Cell Alternative 


F.D.A. Clears Way for Embryonic Stem Cell Trial Using Patients
http://prescriptions.blogs.nyt...using-patients/


Quote:
The F.D.A. had initially cleared the clinical trial in January 2009, in what was viewed at the time as a research milestone.

But before the study could begin, the agency then put a so-called hold on the trial after cysts were discovered in some mice injected with the cells. Geron had to do another mouse study and develop better ways to check the purity of its cells.

On Friday, the company announced in a press release that the F.D.A. had lifted the hold. Geron shares rose in morning trading.
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Posted: 8/3/2010 10:45 AM

Re: Researchers Find Safer Way to Produce Stem Cell Alternative 


VUGear wrote: F.D.A. Clears Way for Embryonic Stem Cell Trial Using Patients
http://prescriptions.blogs.nyt...using-patients/

Quote:...before the study could begin, the agency then put a so-called hold on the trial after cysts were discovered in some mice injected with the cells...
Gear, I go back & forth in my belief that embryonic stem cells will ever prove useful, because on the one hand, they're either analogous to cancer cells (or they're not analogous, they ARE basically cancer cells), & OTOH we can in theory learn to control their nature to the same extent that non-embyonic stem cells are controlled/controllable.

You keep up with this stuff (or at least give an excellent impression of doing so!  wink); and tho I know you've got strong preferences involved, I'd appreciate hearing your thoughts on the analogousness/equivalence between ESCs & cancer cells. 

I've heard other explanations of cancer cells that are not analogous to stem cells of any type (severe chromosome damage, so that they are not 'human' cells at all anymore, for example). I'd be amazed if there are not several different ways in which cells can become cancerous.

I realize that if you knew any of these answers for absolute sure, you wouldn't be posting here, you'd be too busy receiving your Nobel prize, but I'd like to hear your thoughts.
They laughed when I said I was going to be a comedian. They're not laughing now. -Bob Monkhouse (1928-2003)
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Posted: 8/5/2010 4:25 PM

Re: Researchers Find Safer Way to Produce Stem Cell Alternative 



vebiltdervan wrote:
You keep up with this stuff (or at least give an excellent impression of doing so!  wink); and tho I know you've got strong preferences involved, I'd appreciate hearing your thoughts on the analogousness/equivalence between ESCs & cancer cells. 

I've heard other explanations of cancer cells that are not analogous to stem cells of any type (severe chromosome damage, so that they are not 'human' cells at all anymore, for example). I'd be amazed if there are not several different ways in which cells can become cancerous.

I'm afraid I'm not too well-versed on that subject; the analogousnessticity seems like it might be a subjective thing.  I'll stay on the lookout though.
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Posted: 8/5/2010 4:26 PM

Re: Researchers Find Safer Way to Produce Stem Cell Alternative 


Adult stem cell research far ahead of embryonic
http://www.google.com/hostedne...ZYjYvgD9HB46M80


Quote:
Embryonic cells may indeed be used someday to grow replacement tissue or therapeutic material for diseases like Parkinson's or diabetes. Just on Friday, a biotech company said it was going ahead with an initial safety study in spinal cord injury patients. Another is planning an initial study in eye disease patients later this year.

But in the near term, embryonic stem cells are more likely to pay off as lab tools, for learning about the roots of disease and screening potential drugs.

[ ... ]

Some of the new approaches, like the long-proven treatments, are based on the idea that stem cells can turn into other cells. Einhorn said the ankle-repair technique, for example, apparently works because of cells that turn into bone and blood vessels. But for other uses, scientists say they're harnessing the apparent abilities of adult stem cells to stimulate tissue repair, or to suppress the immune system.

"That gives adult stem cells really a very interesting and potent quality that embryonic stem cells don't have," says Rocky Tuan of the University of Pittsburgh.
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Posted: 8/6/2010 10:21 AM

Re: Researchers Find Safer Way to Produce Stem Cell Alternative 


VUGear wrote: ...I'm afraid I'm not too well-versed on that subject; the analogousnessticity seems like it might be a subjective thing.  I'll stay on the lookout though.
Well, I think perhaps we can limit the concept of analogousness-ness between stem cells & cancer cells to the case where cancer cells switch to full-time growth, as an aspect of pluripotency, without any observable damage to the chromosomes, i.e. genetic mutation. In that case, they'd be acting 'normally', but in a deadly wrong 'context'. As opposed to mutated cells that are just plain acting wrong, without the slightest apology.

I expect that over at VU hospital, there may be researchers working on precisely this problem, if only we knew who to go irritate.

Thanks for keeping your lookout!
They laughed when I said I was going to be a comedian. They're not laughing now. -Bob Monkhouse (1928-2003)
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Posted: 8/6/2010 10:34 AM

Re: Researchers Find Safer Way to Produce Stem Cell Alternative 


Paralyzed Iraqi War Veteran Will Be First to Receive Adult Stem Cells to Treat Spinal Cord Injuries at TCA Cellular Therapy
http://www.businesswire.com/po...amp;newsLang=en



Quote:
TCA Cellular Therapy, LLC has enrolled its first patient to participate in the U.S. Food and Drug Administration (FDA) first adult stem cell clinical trial to treat spinal cord injuries. Enrollee and Marine Veteran, Matt Cole was paralyzed from the chest down in a 2005 insurgent attack in Iraq.

[ ... ]

“Many spinal cord injury patients have no effective treatment available at this time,” stated Dr. Gutnisky. “I’m very encouraged by the results of the pre-clinical trials and anticipate this may become a significant therapy for these patients in the near future.”

Utilizing TCA Cellular’s proprietary therapy, a couple of thousand adult stem cells have been extracted from the patient’s own bone marrow, Mesenchymal Stem Cells have been separated, purified, multiplied to millions and will be infused into Cole’s spinal cord later this month.

“In theory we expect the cells to repair damaged neurons,” explained TCA Cellular president, Dr. Lasala. “At minimum, our team expects this therapy will provide some improvement to the patient’s motory and sensory functions with no side effects.”
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Posted: 8/7/2010 10:44 AM

Re: Researchers Find Safer Way to Produce Stem Cell Alternative 


Stem cells used to grow new windpipe for British teen with cancer
http://www.telegraph.co.uk/hea...ith-cancer.html


Quote:
A British teenager has been given a new windpipe grown from her own stem cells in a pioneering operation.

The 19-year-old has now been discharged after having the procedure in Italy.

She was suffering from a rare form of trachea cancer and would have died without the operation.

Doctors took tissue from her nose and bone marrow stem cells to create a trachea biologically identical to the original organ.

The girl's stem cells were grafted on to the cartilage of another trachea, from a donor, which had been stripped of its own cells.

A similar operation was conducted on British boy in March but in that case the stem cells for the windpipe were grown inside the body. For this latest trachea transplant stem cells were used to grow a new trachea outside the body.

Because the new trachea contained no cells from another person, no anti-rejection drugs were needed.

Doctor Walter Giovannini, from AOU Careggi Hospital, in Florence, Italy, said the British woman was speaking after only three or four days after the surgeries on July 3 and 13.

[ ... ]

"While trachea cancer is rare, it is very difficult to treat because it is resistant to chemotherapy and radiation and transplants of mechanical devices to replace the windpipe have not been effective.

"It takes two to three months for the stem cells to completely cover the trachea, creating a new organ.

"In the meantime, the windpipe is functional without the cells - acting as a sort of mechanical device before the stem cells transform it into an organ."

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Posted: 8/21/2010 9:42 AM

Re: Researchers Find Safer Way to Produce Stem Cell Alternative 


Scientists successfully use human induced pluripotent stem cells to treat Parkinson's in rodents
http://www.eurekalert.org/pub_...a-ssu081610.php


Quote:
Researchers at the Buck Institute for Age Research have successfully used human induced pluripotent stem cells (iPSCs) to treat rodents afflicted with Parkinson's Disease (PD). The research, which validates a scalable protocol that the same group had previously developed, can be used to manufacture the type of neurons needed to treat the disease and paves the way for the use of iPSC's in various biomedical applications. Results of the research, from the laboratory of Buck faculty Xianmin Zeng, Ph.D., are published August 16, 2010 in the on-line edition of the journal Stem Cells.

Human iPSC's are a "hot" topic among scientists focused on regenerative medicine. "These cells are reprogrammed from existing cells and represent a promising unlimited source for generating patient-specific cells for biomedical research and personalized medicine," said Zeng, who is lead author of the study. "Human iPSCs may provide an end-run around immuno-rejection issues surrounding the use of human embryonic stem cells (hESCs) to treat disease," said Zeng. "They may also solve bioethical issues surrounding hESCs."
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  • MATheta
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Posted: 8/22/2010 8:53 AM

Re: Researchers Find Safer Way to Produce Stem Cell Alternative 


I have an appreciation for the information of this thread.  It will be only a matter of time before the taking of tissue from every major organ of a human and preserving it so that when a person is diagnosed with a life threatening situation.  At that point a piece of that preserved tissue is regenerated and a whole new organ is grown with the same DNA so there is no rejection by the host and is then used to replace the damaged or organ.  The person is now back to the picture of health and vitality. 

At the present time the mechanics had been the issue, but when the above plays out and is available for everyone then there will emerge new moral and ethical questions with which we are not ready to deal.  Suppose I am ready for my third liver transplant at the age of 211.  Will be allowed to turn down the process and be allowed to die?  Will this decision not be the same as an act of suicide?  Is there not a sense of each person either trying or being allowed to play God?
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Posted: 8/22/2010 12:31 PM

Re: Researchers Find Safer Way to Produce Stem Cell Alternative 



MATheta wrote: Suppose I am ready for my third liver transplant at the age of 211.  Will be allowed to turn down the process and be allowed to die?  Will this decision not be the same as an act of suicide?  Is there not a sense of each person either trying or being allowed to play God?
It seems to me that refusal of treatment has always been an allowable option; DNR is just one example.
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Posted: 8/29/2010 8:37 AM

Re: Researchers Find Safer Way to Produce Stem Cell Alternative 


U.S. court rules against Obama's stem cell policy
http://www.reuters.com/article/idUSTRE67M4HA201008 23


Quote:
A U.S. district court issued a preliminary injunction on Monday stopping federal funding of human embryonic stem cell research, in a slap to the Obama administration's new guidelines on the sensitive issue.

The court ruled in favor of a suit filed in June by researchers who said human embryonic stem cell research involved the destruction of human embryos.

Judge Royce Lamberth granted the injunction after finding the lawsuit would likely succeed because the guidelines violated law banning the use of federal funds to destroy human embryos.

"(Embryonic stem cell) research is clearly research in which an embryo is destroyed," Lamberth wrote in a 15-page ruling. The Obama administration could appeal his decision or try to rewrite the guidelines to comply with U.S. law.
So... what's "the status quo" of funding?  Perhaps the previous Administration's policy, since that was the status quo for over seven years yet even that policy would appear to violate Judge Lamberth's views of the Dickey Amendment's intent.

And does this mean Diana DeGette and Mike Castle's attempt to overthrow the Dickey Amendment ( http://www.foxnews.com/politic...e-restrictions/ ) will be seriously considered?
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Posted: 8/29/2010 8:42 AM

Re: Researchers Find Safer Way to Produce Stem Cell Alternative 


Media Coverage: Political and Research Implications of hESC Ruling
http://californiastemcellrepor...d-research.html


Quote:
Here are some excerpts and links to interesting coverage of yesterday's federal court ruling on stem cell research.

Text of the judge's ruling from the Washington Post.
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Posted: 8/30/2010 8:24 AM

Re: Researchers Find Safer Way to Produce Stem Cell Alternative 


White House looks at ways round stem cell ruling
http://www.google.com/hostedne...MzSpcP-pXmpBF1g



Quote:
The White House said Tuesday it was examining a court's decision to put a temporary block on federal funding for embryonic stem cell research to see how it could keep the "life-saving" work going.

A US court on Monday ordered a halt to federal funding of the research, which President Barack Obama had authorized, saying it involved the destruction of human embryos.

"The president said very plainly that this is important, life-saving research," spokesman Bill Burton told reporters. "We're reviewing all possibilities."

"We're reviewing it so we can keep this important, potentially life-saving research moving forward in the most ethical way possible," he added.
Wouldn't the "most ethical way possible" mean not destroying embryos in the process?
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Posted: 8/30/2010 10:07 PM

Re: Researchers Find Safer Way to Produce Stem Cell Alternative 


Stem Cells, Life, and the Law
http://www.nationalreview.com/...law-adam-keiper



Quote:
In August 2001, Bush announced a compromise policy: He would use federal dollars to fund research on lines of cells derived from embryos that had been destroyed before his announcement, but not on any lines created after the announcement. That way, the availability of federal dollars would not act as an encouragement to destroy embryos in the future. This, Bush believed, was in line with both the letter and the spirit of the Dickey-Wicker Amendment.

Almost immediately, the Left attacked that policy, claiming that it was deceitful (not so), that it caused American researchers to fall behind the rest of the world (demonstrably false), and that it was part of a larger Republican “war on science” (ludicrous). To be sure, pro-life critics could truthfully criticize the Bush administration for not going far enough to protect human embryos. And scientists could correctly criticize the Bush policy for slowing somewhat the pace of their research — moral restraints will have that effect. But imperfect though it was, the Bush policy was a reasonable compromise that promoted research without turning the destruction of human embryos into a national project.

[ ... ]

Whichever way the matter is finally resolved in the courts, it is certainly a great improvement to be asking this question — does the research being funded involve the destruction of human embryos? — and presuming that if the answer is yes, then the research should not be funded, rather than debating whether the destruction of developing human lives is of any consequence, and whether it should be supported by taxpayer funds. Putting the question this way, and presuming the incalculable moral significance of human life, was certainly the intent of the Dickey-Wicker Amendment, and should be the aim of any decent society.
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Posted: 9/14/2010 8:48 PM

Re: Researchers Find Safer Way to Produce Stem Cell Alternative 


Bioethicists: induced pluripotent stem cells from skin are as fraught with ethical questions as embryonic stem cells.

"Not only do many of the ethical challenges posed by embryonic stem cells remain, but the relative ease and low cost of iPS techniques, combined with the accessibility of cells, accelerate the need to address futuristic-sounding possibilities such as creating gametes for reproduction."



They laughed when I said I was going to be a comedian. They're not laughing now. -Bob Monkhouse (1928-2003)
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Posted: 10/7/2010 12:10 PM

Stem cells in court, scientists fear for careers 


Stem cells in court, scientists fear for careers:
http://www.nytimes.com/2010/10/06/science/06stem.h tml?th&emc=th

“You have this career plan to do all of this research, and the thought that they could just shut it off is pretty nerve-racking.”
They laughed when I said I was going to be a comedian. They're not laughing now. -Bob Monkhouse (1928-2003)
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Posted: 3/1/2012 6:39 PM

Re: Researchers Find Safer Way to Produce Stem Cell Alternative 


Egg-making stem cells found in adult ovaries
http://www.nature.com/news/egg...ovaries-1.10121

"There's no confirmation that we have baby-making eggs yet, but every other indication is that these cells are the real deal — bona fide oocyte precursor cells," says Tilly. The next step, to test whether the human OSC-derived oocytes can be fertilized and form an early embryo, will require special considerations — namely, private funding to support the work in the United States (federal funding cannot by law be used for any research that will result in the destruction of a human embryo, whatever the source of the embryo) or a licence from the UK Human Fertilisation and Embryology Authority to do the work with collaborators in the United Kingdom.

[ ... ]

[Tefler] notes that there’s still no evidence that the OSCs form new eggs naturally in the body. However, if they could be coaxed in a dish to make eggs that could successfully be used for in vitro fertilization (IVF), it would change the face of assisted reproduction.

"That's a huge ‘if'," admits Tilly. But, he continues, it could mean an unlimited supply of eggs for women who have ovarian tissue that still hosts OSCs. This group could include cancer patients who have undergone sterilizing chemotherapy, women who have gone through premature menopause, or even those experiencing normal ageing. Tilly says that follow-up studies have confirmed that OSCs exist in the ovaries of women well into their 40s.
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