NFL Odds Week 16 - Week Sixteen NFL Football Odds NFL Game Odds 12/22 - 12/23, 2012
| Date & Time | Favorite | Spread | Underdog | Total | Money Odds |
| 12/22 8:30 ET | Atlanta | -3.5 | At Detroit | 50.5 | -$195 +$170 |
| 12/23 1:00 ET | At Green Bay | -12.5 | Tennessee | 44.5 | -$875 +$625 |
| 12/23 1:00 ET | At Carolina | -8.5 | Oakland | 46 | -$410 +$340 |
| 12/23 1:00 ET | At Miami | -4.5 | Buffalo | 41.5 | -$230 +$190 |
| 12/23 1:00 ET | At Pittsburgh | -3.5 | Cincinnati | 41.5 | -$185 +$165 |
| 12/23 1:00 ET | New England | -14.5 | At Jacksonville | 50.5 | -$1300 +$800 |
| 12/23 1:00 ET | Indianapolis | -7 | At Kansas City | 41.5 | -$300 +$250 |
| 12/23 1:00 ET | At Dallas | -2.5 | New Orleans | 52 | -$145 +$125 |
| 12/23 1:00 ET | Washington | -6.5 | At Philadelphia | 45 | -$300 +$250 |
| 12/23 1:00 ET | At Tampa Bay | -3 | St. Louis | 44 | -$165 +$145 |
| 12/23 4:25 ET | NY Giants | -2.5 | At Baltimore | 47 | -$145 +$125 |
| 12/23 1:00 ET | At Houston | -7.5 | Minnesota | 45 | -$370 +$310 |
| 12/23 4:05 ET | At Denver | -13 | Cleveland | 44.5 | -$1200 +$800 |
| 12/23 4:25 ET | Chicago | -5.5 | At Arizona | 36.5 | -$245 +$205 |
| 12/23 8:30 ET | At Seattle | PK | San Francisco | 39 | -$110 -$110 |
| 12/23 1:00 ET | At NY Jets | -2.5 | San Diego | 37.5 | -$145 +$125 |
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